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Article

Emergence of genetic instability in children treated for leukemia.

Science (New York, N.Y.) - 21 Apr 2000

Finette B A, Homans A C, Albertini R J

Abstract excerpt

T cells from patients who had received chemotherapy for B-lineage acute lymphocytic leukemia were studied to determine whether genetic instability, a principal characteristic of cancer cells, can also occur in nonmalignant cells. Consistent with expectations for a genetic instability phenotype, multiple mutations were detected in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) reporter gene in...

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Source

Identifiers

PMID: 10775110
DOI: 10.1126/science.288.5465.514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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