Article
Temporal delineation of sequential HPRT mutations arising in vivo in a T-cell clone with a mutator phenotype.
Mutation research - 20 Feb 2001
Wilson V L, Wade K R, Yin X, Albertini R J
Abstract excerpt
Recurrent mutations in vivo in T-lymphocytes identify clonally restricted genomic instabilities in some individuals. Cell-based assays allow initial recognition of clones with mutator phenotypes, but genotypic selection is required to determine frequencies and temporal sequences of potentially independent mutational events isolated only as complex changes in the same allele. The present work illustrates how two...
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