Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.

Oncogene - 17 Feb 2011

Savelyeva I, Dobbelstein M

Abstract excerpt

Wild-type adenovirus type 5 eliminates p53 through the E1B-55kDa and E4-34kDa gene products. Deletion or mutation of E1B-55kDa has long been thought to confer p53-selective replication of oncolytic viruses. We show here that infection with E1B-defective adenovirus mutants induces massive accumulation of p53, without obvious defects in p53 localization, phosphorylation, conformation and oligomerization....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Adenovirus E1A Proteins
Share to Adenovirus Infections, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Adenoviruses, Human

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to E1A-Associated p300 Protein

Share to Gene Expression Regulation, Viral

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 20935676
DOI: 10.1038/onc.2010.461

Genes

CDKN1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.PMID 20935676Read ↗

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.Semantic proximity Read ↗

The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factorsSemantic proximity Read ↗

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.Semantic proximity Read ↗

Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP proteinSemantic proximity Read ↗

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.Semantic proximity Read ↗

Advances in adenovirus-mediated p53 cancer gene therapySemantic proximity Read ↗

Stabilization of p53 by adenovirus E1A occurs through its amino-terminal region by modification of the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53Semantic proximity Read ↗

Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.Semantic proximity Read ↗

A region in the C‐terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24‐ras mediated transformation, tumorigenesis and metastasis.Semantic proximity Read ↗

p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signalingSemantic proximity Read ↗

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.