Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.

doi:10.1038/onc.2010.461

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Article

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.

Oncogene - 17 Feb 2011

Savelyeva I, Dobbelstein M

Abstract excerpt

Wild-type adenovirus type 5 eliminates p53 through the E1B-55kDa and E4-34kDa gene products. Deletion or mutation of E1B-55kDa has long been thought to confer p53-selective replication of oncolytic viruses. We show here that infection with E1B-defective adenovirus mutants induces massive accumulation of p53, without obvious defects in p53 localization, phosphorylation, conformation and oligomerization....

Topics

Acetylation
Acetyltransferases
Adenovirus E1A Proteins
Adenovirus E1B Proteins
Adenovirus Infections, Human
Adenoviruses, Human
Cell Line
Cyclin-Dependent Kinase Inhibitor p21
E1A-Associated p300 Protein
Gene Expression Regulation, Viral
Humans
Mutation
Promoter Regions, Genetic
Proto-Oncogene Proteins p21(ras)
Sp1 Transcription Factor
Tumor Suppressor Protein p53

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Open in PubMed

Identifiers

PMID: 20935676
DOI: 10.1038/onc.2010.461

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