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Article

Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by coexpression with Id proteins.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998

Nakajima T, Yageta M, Shiotsu K, Morita K, Suzuki M, Tomooka Y, Oda K

Abstract excerpt

The rat 3Y1 derivative cell lines, EId10 and EId23, established by introducing the adenovirus E1A12S, Id-1H, and Id-2H cDNAs linked to the hormone-inducible promoter, express these proteins upon treatment with dexamethasone and elicit apoptosis, although these cell lines express mutated p53. The E1A mutants containing a deletion in either the N terminus or the conserved region 1 were unable to induce apoptosis in...

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Identifiers

PMID: 9724748
DOI: 10.1073/pnas.95.18.10590
PMCID: PMC27939

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Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by coexpression with Id proteins.PMID 9724748Read ↗

The adenovirus E1A domains required for induction of DNA rereplication in G2/M arrested cells coincide with those required for apoptosis.Semantic proximity Read ↗

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