Article
Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by coexpression with Id proteins.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
Nakajima T, Yageta M, Shiotsu K, Morita K, Suzuki M, Tomooka Y, Oda K
Abstract excerpt
The rat 3Y1 derivative cell lines, EId10 and EId23, established by introducing the adenovirus E1A12S, Id-1H, and Id-2H cDNAs linked to the hormone-inducible promoter, express these proteins upon treatment with dexamethasone and elicit apoptosis, although these cell lines express mutated p53. The...
Topics
- Adenovirus E1A Proteins
- Animals
- Apoptosis
- Cell Line
- Dexamethasone
- Helix-Loop-Helix Motifs
- Inhibitor of Differentiation Protein 1
- Mice
- Mice, Knockout
- Mutation
- Protein Binding
- Rats
- Rats, Inbred F344
- Repressor Proteins
- S Phase