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Article

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.

Journal of virology - 1 Jan 2001

Querido E, Morrison M R, Chu-Pham-Dang H, Thirlwell S W, Boivin D, Branton P E, Morisson M R

Abstract excerpt

Complexes containing adenovirus E4orf6 and E1B55K proteins play critical roles in productive infection. Both proteins interact directly with the cellular tumor suppressor p53, and in combination they promote its rapid degradation. To examine the mechanism of this process, degradation of exogenously expressed p53 was analyzed in p53-null human cells infected with adenovirus vectors encoding E4orf6 and/or E1B55K....

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Source

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Identifiers

PMID: 11134283
DOI: 10.1128/JVI.75.2.699-709.2001
PMCID: PMC113966

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.PMID 11134283Read ↗

Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Semantic proximity Read ↗

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Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.Semantic proximity Read ↗

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