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Article

Cortactin modulates cell migration and ring canal morphogenesis during Drosophila oogenesis.

Mechanisms of development - 1 Jan 2004

Somogyi Kálmán, Rørth Pernille

Abstract excerpt

Cortactin is a Src substrate that interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex. We have isolated complete loss-of-function mutants of the single Drosophila cortactin gene. Mutants are viable and fertile, showing that cortactin is not an essential gene. However, cortactin mutants show distinct defects during oogenesis. During oogenesis, Cortactin...

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Identifiers

PMID: 14706700
DOI: 10.1016/j.mod.2003.10.003

Genes

PVR
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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