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Article

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.

The Journal of cell biology - 27 May 2002

Tsuji Takahiro, Ishizaki Toshimasa, Okamoto Muneo, Higashida Chiharu, Kimura Kazuhiro, Furuyashiki Tomoyuki, Arakawa Yoshiki, Birge Raymond B, Nakamoto Tetsuya, Hirai Hisamaru, Narumiya Shuh

Abstract excerpt

The small GTPase Rho acts on two effectors, ROCK and mDia1, and induces stress fibers and focal adhesions. However, how ROCK and mDia1 individually regulate signals and dynamics of these structures remains unknown. We stimulated serum-starved Swiss 3T3 fibroblasts with LPA and compared the effects of C3 exoenzyme, a Rho inhibitor, with those of Y-27632, a ROCK inhibitor. Y-27632 treatment suppressed LPA-induced...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12021256
DOI: 10.1083/jcb.200112107
PMCID: PMC2173402

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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