Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.

The Journal of cell biology - 22 Sept 1997

Dharmawardhane S, Sanders L C, Martin S S, Daniels R H, Bokoch G M

Abstract excerpt

The mechanisms through which the small GTPases Rac1 and Cdc42 regulate the formation of membrane ruffles, lamellipodia, and filopodia are currently unknown. The p21-activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts, suggesting that they may play a role in mediating the effects of these GTPases on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Actins
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Viral

Share to Cytoskeleton

Share to Mutation

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 9298982
DOI: 10.1083/jcb.138.6.1265
PMCID: PMC2132543

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.PMID 9298982Read ↗

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.Semantic proximity Read ↗

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.Semantic proximity Read ↗

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.Semantic proximity Read ↗

p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.Semantic proximity Read ↗

Nuclear Localization and Chromatin Targets of p21-activated Kinase 1Semantic proximity Read ↗

Integrin-mediated signals regulated by members of the rho family of GTPases.Semantic proximity Read ↗

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactionsSemantic proximity Read ↗

WIP participates in actin reorganization and ruffle formation induced by PDGF.Semantic proximity Read ↗

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.Semantic proximity Read ↗

Pak1 and PIX regulate contact inhibition during epithelial wound healing.Semantic proximity Read ↗

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.Semantic proximity Read ↗

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.