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Article

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.

The Journal of cell biology - 22 Sept 1997

Dharmawardhane S, Sanders L C, Martin S S, Daniels R H, Bokoch G M

Abstract excerpt

The mechanisms through which the small GTPases Rac1 and Cdc42 regulate the formation of membrane ruffles, lamellipodia, and filopodia are currently unknown. The p21-activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structur...

Topics

3T3 Cells
Actins
Animals
Cell Membrane
Cell Transformation, Viral
Cytoplasmic Granules
Cytoskeleton
Genes, src
Mice
Mutation
Pinocytosis
Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Pseudopodia

p21-Activated Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 9298982
DOI: 10.1083/jcb.138.6.1265
PMCID: PMC2132543

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9298982-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.PMID 9298982Read ↗

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