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Article

Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.

American journal of physiology. Cell physiology - 1 Nov 2008

Kruchten Anne E, Krueger Eugene W, Wang Yu, McNiven Mark A

Abstract excerpt

Cortactin is an actin-binding protein that is overexpressed in many cancers and is a substrate for both tyrosine and serine/threonine kinases. Tyrosine phosphorylation of cortactin has been observed to increase cell motility and invasion in vivo, although it has been reported to have both positive and negative effects on actin polymerization in vitro. In contrast, serine phosphorylation of cortactin has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18768925
DOI: 10.1152/ajpcell.00238.2008
PMCID: PMC2584996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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