Article
Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors.
Hepatology (Baltimore, Md.) - 1 Apr 2004
Lazarevich Natalia L, Cheremnova Oksana A, Varga Ekaterina V, Ovchinnikov Dmitry A, Kudrjavtseva Elena I, Morozova Olga V, Fleishman Daria I, Engelhardt Natalia V, Duncan Stephen A
Abstract excerpt
Hepatocyte nuclear factors (HNF) play a critical role in development of the liver. Their roles during liver tumorigenesis and progression of hepatocellular carcinomas (HCC) are, however, poorly understood. To address the role of HNFs in tumor progression, we generated a new experimental model in which a highly differentiated slow-growing transplantable mouse HCC (sgHCC) rapidly gives rise in vivo to a highly...
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