Article
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists.
Science (New York, N.Y.) - 27 Jan 1995
Madrenas J, Wange R L, Wang J L, Isakov N, Samelson L E, Germain R N
Abstract excerpt
Small changes in the peptide-major histocompatibility complex (MHC) molecule ligands recognized by antigen-specific T cell receptors (TCRs) can convert fully activating complexes into partially activating or even inhibitory ones. This study examined early TCR-dependent signals induced by such par...
Topics
- Amino Acid Sequence
- Animals
- Clone Cells
- Cytochrome c Group
- Enzyme Activation
- Histocompatibility Antigens Class II
- Interleukin-2
- L Cells
- Ligands
- Lymphocyte Activation
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell