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Article

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists.

Science (New York, N.Y.) - 27 Jan 1995

Madrenas J, Wange R L, Wang J L, Isakov N, Samelson L E, Germain R N

Abstract excerpt

Small changes in the peptide-major histocompatibility complex (MHC) molecule ligands recognized by antigen-specific T cell receptors (TCRs) can convert fully activating complexes into partially activating or even inhibitory ones. This study examined early TCR-dependent signals induced by such partial agonists or antagonists. In contrast to typical agonist ligands, both an antagonist and several partial agonists...

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Source

Identifiers

PMID: 7824949
DOI: 10.1126/science.7824949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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