Article
Production and characterization of a novel monoclonal antibody against phosphorylated T cell receptor zeta chain.
Hybridoma - 1 Apr 1997
Conrad P J, Seng T, Barbosa J, Vasavada H, Blue M L
Abstract excerpt
One of the earliest events following T cell receptor (TCR) triggering is the activation of the protein kinase Lck and induction of tyrosine phosphorylation of zeta, the major signal transduction subunit of the T cell receptor complex. Here we report the generation and characterization of a monoclonal antibody specific for human phosphozeta. The antibody was produced by immunizing mice with a truncated recombinant...
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