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Article

Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease.

Neurology - 1 Jul 1998

Craft S, Teri L, Edland S D, Kukull W A, Schellenberg G, McCormick W C, Bowen J D, Larson E B

Abstract excerpt

BACKGROUND: The apolipoprotein E-epsilon4 (APOE-epsilon4) allele is a powerful genetic risk factor for the development of Alzheimer's disease (AD). AD patients who are APOE-epsilon4 homozygotes have an earlier age at onset, increased amyloid burden, and decreased acetylcholine levels--findings that suggest differences in disease severity or rate of progression. Studies of genotype differences in rate of decline,...

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Source

Identifiers

PMID: 9674794
DOI: 10.1212/wnl.51.1.149

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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