Article
Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease.
Neurology - 1 Jul 1998
Craft S, Teri L, Edland S D, Kukull W A, Schellenberg G, McCormick W C, Bowen J D, Larson E B
Abstract excerpt
BACKGROUND: The apolipoprotein E-epsilon4 (APOE-epsilon4) allele is a powerful genetic risk factor for the development of Alzheimer's disease (AD). AD patients who are APOE-epsilon4 homozygotes have an earlier age at onset, increased amyloid burden, and decreased acetylcholine levels--findings th...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Disease Progression
- Female
- Genotype
- Homozygote
- Humans
- Male