Article
The absence of an apolipoprotein epsilon4 allele is associated with a more aggressive form of Alzheimer's disease.
Annals of neurology - 1 May 1997
Stern Y, Brandt J, Albert M, Jacobs D M, Liu X, Bell K, Marder K, Sano M, Albert S, Del-Castillo Castenada C, Bylsma F, Tycko B, Mayeux R
Abstract excerpt
We investigated the relationship between APOE genotype and rate of disease progression and survival in 99 patients with probable Alzheimer's disease (AD) who were followed biannually for up to 6 years. Patients were stratified into two groups, those with and without at least one APOE epsilon4 allele. The rate of decline in modified Mini-Mental State Examination scores was slower, the presence of extrapyramidal...
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