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Article

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.

Neurology - 11 May 2021

Qian Jing, Betensky Rebecca A, Hyman Bradley T, Serrano-Pozo Alberto

Abstract excerpt

OBJECTIVE: To test the hypothesis that the APOE genotype is a significant driver of heterogeneity in Alzheimer disease (AD) clinical progression, which could have important implications for clinical trial design and interpretation. METHODS: We applied novel reverse-time longitudinal models to analyze the trajectories of Clinical Dementia Rating Sum of Boxes (CDR-SOB) and Mini-Mental State Examination (MMSE)...

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Identifiers

PMID: 33771840
DOI: 10.1212/WNL.0000000000011883
PMCID: PMC8166439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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