Article
APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease.
Neurology - 6 May 2008
Cosentino S, Scarmeas N, Helzner E, Glymour M M, Brandt J, Albert M, Blacker D, Stern Y
Abstract excerpt
OBJECTIVE: To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD). METHODS: Individuals were recruited from two longitudinal cohort studies-the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predictors Study (clinic-based)--and were followed for an average of 4 years. Three samples of participants diagnosed...
Topics
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Apolipoprotein E4
- Cognition Disorders
- Cohort Studies
- DNA Mutational Analysis
- Disease Progression
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype