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Article

APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease.

Neurology - 6 May 2008

Cosentino S, Scarmeas N, Helzner E, Glymour M M, Brandt J, Albert M, Blacker D, Stern Y

Abstract excerpt

OBJECTIVE: To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD). METHODS: Individuals were recruited from two longitudinal cohort studies-the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predictors Study (clinic-based)--and were followed for an average of 4 years. Three samples of participants diagnosed...

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Identifiers

PMID: 18401023
DOI: 10.1212/01.wnl.0000304038.37421.cc
PMCID: PMC2676693

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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