Article
Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme.
Molecular and cellular biology - 1 Aug 1998
Lee T I, Wyrick J J, Koh S S, Jennings E G, Gadbois E L, Young R A
Abstract excerpt
Activation of protein-encoding genes involves recruitment of an RNA polymerase II holoenzyme to promoters. Since the Srb4 subunit of the holoenzyme is essential for expression of most class II genes and is a target of at least one transcriptional activator, we reasoned that suppressors of a temperature-sensitive mutation in Srb4 would identify other factors generally involved in regulation of gene expression. We...
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