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Article

Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast.

Genetics - 1 Aug 2000

Lee M, Chatterjee S, Struhl K

Abstract excerpt

The Cyc8-Tup1 corepressor complex is targeted to promoters by pathway-specific DNA-binding repressors, thereby inhibiting the transcription of specific classes of genes. Genetic screens have identified mutations in a variety of Pol II holoenzyme components (Srb8, Srb9, Srb10, Srb11, Sin4, Rgr1, Rox3, and Hrs1) and in the N-terminal tails of histones H3 and H4 that weaken repression by Cyc8-Tup1. Here, we analyze...

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Identifiers

PMID: 10924455
DOI: 10.1093/genetics/155.4.1535
PMCID: PMC1461184

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Source receipt: pubmed, retrieved 7 Sept 2026.

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