Article
The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.
Molecular and cellular biology - 1 Jan 2005
Lenssen Eve, James Nicole, Pedruzzi Ivo, Dubouloz Frédérique, Cameroni Elisabetta, Bisig Ruth, Maillet Laurent, Werner Michel, Roosen Johnny, Petrovic Katarina, Winderickx Joris, Collart Martine A, De Virgilio Claudio
Abstract excerpt
The Ccr4-Not complex is a conserved global regulator of gene expression, which serves as a regulatory platform that senses and/or transmits nutrient and stress signals to various downstream effectors. Presumed effectors of this complex in yeast are TFIID, a general transcription factor that associates with the core promoter, and Msn2, a key transcription factor that regulates expression of stress-responsive...
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