Article
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.
Cell - 29 May 1992
Koleske A J, Buratowski S, Nonet M, Young R A
Abstract excerpt
The RNA polymerase II large subunit carboxy-terminal domain (CTD) plays a role in transcription initiation, but its mechanism of action is not well understood. We have investigated the function of the SRB2 gene, which was isolated as a dominant suppressor of CTD truncation mutations. The allele specificity of this suppressor indicates that SRB2 and the CTD are involved in the same function. Indeed, cells lacking...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Chromatography, Affinity
- Fungal Proteins
- Genes, Suppressor
- Mediator Complex
- Molecular Sequence Data
- Mutation
- RNA Polymerase II
- Recombinant Fusion Proteins