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Article

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.

Cell - 29 May 1992

Koleske A J, Buratowski S, Nonet M, Young R A

Abstract excerpt

The RNA polymerase II large subunit carboxy-terminal domain (CTD) plays a role in transcription initiation, but its mechanism of action is not well understood. We have investigated the function of the SRB2 gene, which was isolated as a dominant suppressor of CTD truncation mutations. The allele specificity of this suppressor indicates that SRB2 and the CTD are involved in the same function. Indeed, cells lacking...

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PMID: 1591782
DOI: 10.1016/0092-8674(92)90298-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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