Article
Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein.
Nucleic acids research - 1 Apr 2014
Koster Maria J E, Yildirim Asli D, Weil P Anthony, Holstege Frank C P, Timmers H Th Marc
Abstract excerpt
Chromatin structure in transcribed regions poses a barrier for intragenic transcription. In a comprehensive study of the yeast chromatin remodelers and the Mot1p-NC2 regulators of TATA-binding protein (TBP), we detected synthetic genetic interactions indicative of suppression of intragenic transcription. Conditional depletion of Mot1p or NC2 in absence of the ISW1 remodeler, but not in the absence of other...
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