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Article

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.

Molecular and cellular biology - 1 Oct 1999

Bai Y, Salvadore C, Chiang Y C, Collart M A, Liu H Y, Denis C L

Abstract excerpt

The CCR4-NOT complex (1 mDa in size), consisting of the proteins CCR4, CAF1, and NOT1 to NOT5, regulates gene expression both positively and negatively and is distinct from other large transcriptional complexes in Saccharomyces cerevisiae such as SNF/SWI, TFIID, SAGA, and RNA polymerase II holoenzyme. The physical and genetic interactions between the components of the CCR4-NOT complex were investigated in order...

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Source

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Identifiers

PMID: 10490603
DOI: 10.1128/MCB.19.10.6642
PMCID: PMC84645

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.PMID 10490603Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.Semantic proximity Read ↗

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.Semantic proximity Read ↗

The essential function of Not1 lies within the Ccr4-Not complex.Semantic proximity Read ↗

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.Semantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex.Semantic proximity Read ↗

The Ccr4-Not complex interacts with the mRNA export machinery.Semantic proximity Read ↗

A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAsSemantic proximity Read ↗

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