Article
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
Cancer - 15 Jul 1998
Xu J, Gimenez-Conti I B, Cunningham J E, Collet A M, Luna M A, Lanfranchi H E, Spitz M R, Conti C J
Abstract excerpt
BACKGROUND: Epidemiologic studies have indicated that environmental and personal habits, particularly tobacco use and alcohol abuse, are major etiologic factors in the induction and progression of head and neck squamous cell carcinomas (HNSCC). Molecular studies have focused on HNSCC related to s...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Female
- Gene Expression
- Genes, bcl-1
- Genes, ras
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mouth Neoplasms
- Mutation
- Plants, Toxic
- Retinoblastoma Protein
- Smoking
- Tobacco, Smokeless