Article
Absence of p53 mutations in squamous carcinomas of the tongue in nonsmoking and nondrinking patients younger than 40 years.
Archives of otolaryngology--head & neck surgery - 1 May 1997
Sorensen D M, Lewark T M, Haney J L, Meyers A D, Krause G, Franklin W A
Abstract excerpt
BACKGROUND: Although carcinoma of the tongue usually occurs in patients older than 60 years, up to 4% of these tumors may occur in patients younger than 40 years. Many of the younger patients with this tumor have had no exposure or brief exposure to tobacco smoke or alcohol consumption, to which...
Topics
- Adult
- Alcohol Drinking
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Female
- Humans
- Immunohistochemistry
- Lymph Nodes
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Smoking
- Tongue Neoplasms
- Tumor Suppressor Protein p53