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Article

p130 and p107 Use a Conserved Domain To Inhibit Cellular Cyclin-Dependent Kinase Activity†

1 Jul 1997

Abstract excerpt

The pRB-related proteins p107 and p130 are thought to suppress growth in part through their associations with two important cell cycle kinases, cyclin A-cdk2 and cyclin E-cdk2, and transcription factor E2F. Although each protein plays a critical role in cell proliferation, the functional consequences of the association among growth suppressor, cyclin-dependent kinase, and transcription factor have remained...

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Identifiers

PMID: 9199292
DOI: 10.1128/mcb.17.7.3566

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p130 and p107 Use a Conserved Domain To Inhibit Cellular Cyclin-Dependent Kinase Activity†PMID 9199292Read ↗

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.Semantic proximity Read ↗

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1Semantic proximity Read ↗

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Semantic proximity Read ↗

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.Semantic proximity Read ↗

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family membersSemantic proximity Read ↗

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear LocalizationSemantic proximity Read ↗

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsSemantic proximity Read ↗

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinomaSemantic proximity Read ↗

E2F-5, a New E2F Family Member That Interacts with p130 In VivoSemantic proximity Read ↗

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Semantic proximity Read ↗

Inactivation of pRB-Related Proteins p130 and p107 Mediated by the J Domain of Simian Virus 40 Large T AntigenSemantic proximity Read ↗

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