Article
Human cells arrest in S phase in response to adenovirus 12 E1A.
Virology - 10 May 1998
Grand R J, Ibrahim A P, Taylor A M, Milner A E, Gregory C D, Gallimore P H, Turnell A S
Abstract excerpt
It has previously been shown that following viral infection, Ad5 E1A induces cell cycle progression of quiescent rodent cells, leading to DNA synthesis and mitosis. Here we have examined the effect of Ad12 E1A on the cell cycle characteristics of human cells. Human tumor (A549, KB, and HeLa) cells were infected with Ad12 d/620, a mutant virus which has a lesion in the E1B gene and essentially expresses only E1A....
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