Article
An E2F dominant negative mutant blocks E1A induced cell cycle progression.
Oncogene - 1 Sept 1994
Dobrowolski S F, Stacey D W, Harter M L, Stine J T, Hiebert S W
Abstract excerpt
E2F is a cellular transcription factor that is regulated during the cell cycle through interactions with the product of the retinoblastoma susceptibility gene (RB1) and the pRb-like p107 and p130 proteins. Analysis of mutations within both adenovirus E1A and pRb, which affected their ability to r...
Topics
- 3T3 Cells
- Adenovirus E1A Proteins
- Animals
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- DNA
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Genes, myc
- Glutathione Transferase
- HeLa Cells
- Humans
- Mice
- Mutation
- Retinoblastoma-Binding Protein 1
- Transcription Factor DP1