Article
Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous.
The Journal of investigative dermatology - 1 Jul 2015
Aoki Hitomi, Tomita Hiroyuki, Hara Akira, Kunisada Takahiro
Abstract excerpt
It is well established that cell-intrinsic signaling through the receptor tyrosine kinase KIT is critical for the development of neural crest-derived melanocytes. Nevertheless, it is not entirely clear whether Kit acts exclusively in a melanocyte-autonomous manner or in addition indirectly through other cell types. To address this question in vivo, we generated a targeted allele of Kit that allowed for CRE...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.