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Article

Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice.

Molecular and cellular biology - 1 Nov 1995

De Sepulveda P, Guenet J L, Panthier J J

Abstract excerpt

The mouse W locus encodes Kit, the receptor tyrosine kinase for stem cell factor (SCF). Kit is required for several developmental processes, including the proliferation and survival of melanoblasts. Because of the nearly complete failure of Wrio/+ melanoblasts to colonize the skin, the costs of Wrio/+ mice are characterized by a majority of white hairs interspersed among pigmented hairs, giving a roan effect....

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Identifiers

PMID: 7565742
DOI: 10.1128/MCB.15.11.5898
PMCID: PMC230841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice.PMID 7565742Read ↗

Instability at the W/c-kit locus in mice: analysis of melanocyte cell lines derived from reversion spots.Semantic proximity Read ↗

recessive spotting: a linked locus that interacts with W/Kit but is not allelic.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

Evidence for mitotic recombination in Wei/+ heterozygous mice.Semantic proximity Read ↗

Spontaneous malignant transformation of melanocytes explanted from Wf/Wf mice with a Kit kinase-domain mutation.Semantic proximity Read ↗

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.Semantic proximity Read ↗

Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse.Semantic proximity Read ↗

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

Mice transgenic for Kit(V620A): recapitulation of piebaldism but not progressive depigmentation seen in humans with this mutation.Semantic proximity Read ↗

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.Semantic proximity Read ↗

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