Article
p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation.
Cancer research - 1 Jul 1998
Casamassimi A, Miano M G, Porcellini A, De Vita G, de Nigris F, Zannini M, Di Lauro R, Russo T, Avvedimento V E, Fusco A
Abstract excerpt
Expression of mutated versions of the p53 gene deranged the differentiation program of thyroid cells and resulted in deregulated growth. Specifically, p53 mutants in several residues of the DNA-binding region induced thyrotropin (TSH) -independent growth and inhibition of the expression of thyroid-specific genes. The loss of the differentiated phenotype invariably correlated with the blockage of the expression of...
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