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Article

Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.

Molecular biology of the cell - 1 Nov 2008

Rocha Ana Sofia, Paternot Sabine, Coulonval Katia, Dumont Jacques E, Soares Paula, Roger Pierre P

Abstract excerpt

How cyclic AMP (cAMP) could positively or negatively regulate G1 phase progression in different cell types or in cancer cells versus normal differentiated counterparts has remained an intriguing question for decades. At variance with the cAMP-dependent mitogenesis of normal thyroid epithelial cells, we show here that cAMP and cAMP-dependent protein kinase activation inhibit S-phase entry in four thyroid carcinoma...

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Source

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Identifiers

PMID: 18799615
DOI: 10.1091/mbc.e08-06-0617
PMCID: PMC2575166

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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