Article
3',5'-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1992
Woloshin P I, Walton K M, Rehfuss R P, Goodman R H, Cone R D
Abstract excerpt
The thyroid follicular cell requires elevated levels of cAMP for normal growth and optimal expression of the differentiated phenotype. The recent discovery of cAMP-regulated enhancer binding (CREB) proteins prompted us to analyze the possible role of these transcription factors in controlling thy...
Topics
- 3T3 Cells
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Cyclic AMP
- Cyclic AMP Response Element-Binding Protein
- DNA
- Gene Expression
- Kinetics
- Mice
- Mice, Inbred BALB C
- Phenotype
- RNA, Messenger
- Rats
- Recombinant Proteins
- Thymidine