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Article

Pivotal role of the RB family proteins in in vitro thyroid cell transformation.

Experimental cell research - 1 Nov 2000

Iuliano R, Trapasso F, Stella A, Le Pera I, Melillo R M, Bruni P, Baldassarre G, Chiariotti L, Santoro M, Viglietto G, Fusco A

Abstract excerpt

Rat thyroid differentiated cells (PC Cl 3) are an excellent model system with which to study the interaction between differentiation and cell transformation. We previously demonstrated that PC Cl 3 cells expressing the adenovirus E1A gene no longer depend on thyrotropin for growth and do not express thyroid differentiation markers. Here we show that an E1A mutant unable to bind the RB protein failed to transform...

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Identifiers

PMID: 11035920
DOI: 10.1006/excr.2000.5023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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