Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of the Smad4 C324Y mutation on thyroid cell proliferation.

International journal of oncology - 1 Jun 2013

D'Inzeo Sonia, Nicolussi Arianna, Nardi Francesco, Coppa Anna

Abstract excerpt

Smad4 is a key mediator of the transforming growth factor-β (TGF-β) superfamily that is involved in the control of cell proliferation and differentiation. We recently demonstrated that a Smad4 mutation, Smad4 C324Y, isolated from nodal metastases of papillary thyroid carcinoma, causes an increase of TGF-β signaling, responsible for the acquisition of transformed phenotype and invasive behaviour in thyroid cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Smad3 Protein
Share to Cyclic AMP Response Element-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Smad4 Protein

Share to Thyroglobulin

Share to Thyroid Cancer, Papillary

Share to Thyroid Gland

Share to Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 23591524
DOI: 10.3892/ijo.2013.1908
PMCID: PMC3699576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the Smad4 C324Y mutation on thyroid cell proliferation.PMID 23591524Read ↗

A novel human Smad4 mutation is involved in papillary thyroid carcinoma progression.Semantic proximity Read ↗

SMAD4 gene promoter mutations in patients with thyroid tumors.Semantic proximity Read ↗

Consequences of Mutations and Abnormal Expression of SMAD4 in Tumors and T CellsSemantic proximity Read ↗

A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-beta signals.Semantic proximity Read ↗

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.Semantic proximity Read ↗

Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.Semantic proximity Read ↗

Functional characteristics of a novel SMAD4 mutation from thoracic aortic aneurysms (TAA).Semantic proximity Read ↗

Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.Semantic proximity Read ↗

Definition of smad3 phosphorylation events that affect malignant and metastatic behaviors in breast cancer cells.Semantic proximity Read ↗

Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.Semantic proximity Read ↗

Acceleration of BRAFV600E-induced thyroid carcinogenesis by TGFβ signal deficiency in mice.Semantic proximity Read ↗

A novel gain-of-function mutation of TGF-β receptor II promotes cancer progression via delayed receptor internalization in oral squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.