Article
Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.
Endocrinology - 1 Jun 1998
Velasco J A, Acebrón A, Zannini M, Martín-Pérez J, Di Lauro R, Santisteban P
Abstract excerpt
Mechanisms responsible for the lack of thyroid-specific differentiation markers in Ha-ras transformed FRTL-5 cells have been investigated. In vivo cell labeling and immunoprecipitation demonstrate that phosphorylation of the thyroid transcription factor-1 (TTF-1) is clearly reduced in thyroid cel...
Topics
- Amino Acid Sequence
- Cell Differentiation
- Cell Line, Transformed
- Cyclic AMP-Dependent Protein Kinases
- Genes, ras
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Phosphorylation
- Serine
- Thyroid Gland
- Thyroid Nuclear Factor 1
- Transcription Factors