Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer.

doi:10.1038/modpathol.2015.136

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Article

Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2016

Murphy Stephen J, Karnes Robert J, Kosari Farhad, Castellar B Edgardo R Parilla, Kipp Benjamin R, Johnson Sarah H, Terra Simone, Harris Faye R, Halling Geoffrey C, Klein Janet L Schaefer, Nasir Aqsa, Bergstrahl Eric, Rangel Laureano J, Sukov William R, Vasmatzis George, Cheville John C

Abstract excerpt

Patients with clinically insignificant prostate cancer remain a major over-treated population. PTEN loss is one of the most recurrent alterations in prostate cancer associated with an aggressive phenotype, however, the occurrence of PTEN loss in insignificant prostate cancer has not been reported and its role in the separation of insignificant from significant prostate cancer is unclear. An integrated analysis of...

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Identifiers

PMID: 26612463
DOI: 10.1038/modpathol.2015.136

Genes

PTEN
ERG
TMPRSS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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