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Article

Somatic mutation of PTEN in bladder carcinoma.

British journal of cancer - 1 May 1999

Aveyard J S, Skilleter A, Habuchi T, Knowles M A

Abstract excerpt

The tumour suppressor gene PTEN/MMAC1, which is mutated or homozygously deleted in glioma, breast and prostate cancer, is mapped to a region of 10q which shows loss of heterozygosity (LOH) in bladder cancer. We screened 123 bladder tumours for LOH in the region of PTEN. In 53 informative muscle invasive tumours (> or = pT2), allele loss was detected in 13 (24.5%) and allelic imbalance in four tumours (overall...

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Topics

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Share to Carcinoma, Transitional Cell
Share to Chromosomes, Human, Pair 10
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Single-Stranded Conformational

Share to PTEN Phosphohydrolase

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 10360673
DOI: 10.1038/sj.bjc.6690439
PMCID: PMC2362287

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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