Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.

Genes, chromosomes & cancer - 1 Mar 2004

Hermans Karin G, van Alewijk Dirk C, Veltman Joris A, van Weerden Wytske, van Kessel Ad Geurts, Trapman Jan

Abstract excerpt

We examined 11 prostate cancer xenografts and 4 cell lines for chromosome 10 alterations. Conventional comparative genomic hybridization (CGH) and array-based CGH revealed a pattern of loss of distal 10p, gain of proximal 10p and 10q, and loss of distal 10q. In addition, array CGH identified 2 high-level amplifications in the cell line PC3, homozygous deletions of PTEN in PC3 and in the xenografts PCEW, PC133,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Flanking Region
Share to 5' Flanking Region

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 10

Share to Genes, Neoplasm

Share to Genes, Tumor Suppressor

Share to Mice, Nude

Share to Nucleic Acid Hybridization

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 14732919
DOI: 10.1002/gcc.10311

Genes

PTEN
PAPSS2
MINPP1
DMBT1
KLF6
MXI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.PMID 14732919Read ↗

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.Semantic proximity Read ↗

<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplicationsSemantic proximity Read ↗

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?Semantic proximity Read ↗

Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer.Semantic proximity Read ↗

Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer.Semantic proximity Read ↗

Chromosomal deletions and tumor suppressor genes in prostate cancer.Semantic proximity Read ↗

FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcomeSemantic proximity Read ↗

Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene siteSemantic proximity Read ↗

Genomic Rearrangements of PTEN in Prostate CancerSemantic proximity Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.Semantic proximity Read ↗

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.