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Article

Common fragile genes and digestive tract cancers.

Surgery today - 1 Jan 2006

Kuroki Tamotsu, Tajima Yoshitsugu, Furui Jyunichiro, Kanematsu Takashi

Abstract excerpt

FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome. Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively. Interestingly, FHIT and WWOX have similarities: for example, they are both larger than 1 Mb and encompass fragile sites, they both...

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Source

Identifiers

PMID: 16378185
DOI: 10.1007/s00595-005-3094-4

Genes

FHIT
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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