Article
The fragility of a structurally diverse duplication block triggers recurrent genomic amplification.
Nucleic acids research - 11 Jan 2021
Suzuki Ryusuke, Murata Michael M, Manguso Nicholas, Watanabe Takaaki, Mouakkad-Montoya Lila, Igari Fumie, Rahman Md Maminur, Qu Ying, Cui Xiaojiang, Giuliano Armando E, Takeda Shunichi, Tanaka Hisashi
Abstract excerpt
The human genome contains hundreds of large, structurally diverse blocks that are insufficiently represented in the reference genome and are thus not amenable to genomic analyses. Structural diversity in the human population suggests that these blocks are unstable in the germline; however, whether or not these blocks are also unstable in the cancer genome remains elusive. Here we report that the 500 kb block...
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