Article
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
Virology - 5 Jul 1998
Hwang Y T, Smith J F, Gao L, Hwang C B
Abstract excerpt
Two herpes simplex virus mutants containing mutated residues within the conserved Exo III motif of the polymerase gene were previously shown to be defective in 3'-5' exonuclease activity and exhibited extremely high mutation frequencies. In this study, we have shown that these mutants also exhibi...
Topics
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Aphidicolin
- Binding Sites
- Chlorocebus aethiops
- DNA, Viral
- DNA-Directed DNA Polymerase
- Drug Resistance, Microbial
- Enzyme Inhibitors
- Exodeoxyribonuclease V
- Exodeoxyribonucleases