Article
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
Virology - 5 Jul 1998
Hwang Y T, Smith J F, Gao L, Hwang C B
Abstract excerpt
Two herpes simplex virus mutants containing mutated residues within the conserved Exo III motif of the polymerase gene were previously shown to be defective in 3'-5' exonuclease activity and exhibited extremely high mutation frequencies. In this study, we have shown that these mutants also exhibited higher resistance to phosphonoacetic acid and sensitivity to aphidicolin and all nucleoside analogs tested,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.