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Article

Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1.

Journal of virology - 1 Jul 2009

Tian Wang, Hwang Ying T, Lu Qiangsheng, Hwang Charles B C

Abstract excerpt

The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymerases, possesses both polymerase and exonuclease activities. We previously demonstrated that a recombinant virus (YD12) containing a double mutation within conserved exonuclease motif III of the Pol was highly mutagenic and rapidly evolved to contain an additional leucine-to-phenylalanine mutation at residue 774...

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Identifiers

PMID: 19420083
DOI: 10.1128/JVI.00632-09
PMCID: PMC2704776

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