Use of suppressor analysis to identify DNA polymerase mutations in herpes simplex virus which affect deoxynucleoside triphosphate substrate specificity.

Abstract excerpt

Herpes simplex virus DNA polymerase mutations which map in the N-terminal part of the protein and appear to alter deoxynucleoside triphosphate (dNTP) substrate specificity are described. These mutations suppress a drug hypersensitivity associated with the downstream mutation, Aphr10. We suggest t...

Topics

• Aphidicolin
• DNA Mutational Analysis
• DNA-Directed DNA Polymerase
• Deoxyribonucleotides
• Nucleic Acid Synthesis Inhibitors
• Phenotype
• Phosphonoacetic Acid
• Simplexvirus
• Substrate Specificity