Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic Agents

1 Apr 2006

Abstract excerpt

Genetic defects in polymerase eta (pol eta; hRad30a gene) result in xeroderma pigmentosum variant syndrome (XP-V), and XP-V patients are sensitive to sunlight and highly prone to cancer development. Here, we show that pol eta plays a significant role in modulating cellular sensitivity to DNA-targeting anticancer agents. When compared with normal human fibroblast cells, pol eta-deficient cells derived from XP-V...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16603639
DOI: 10.1158/1541-7786.mcr-05-0118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic AgentsPMID 16603639Read ↗

DNA polymerase eta: A potential pharmacological target for cancer therapySemantic proximity Read ↗

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.Semantic proximity Read ↗

Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations.Semantic proximity Read ↗

Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.Semantic proximity Read ↗

Translesion DNA Synthesis and Reinitiation of DNA Synthesis in Chemotherapy ResistanceSemantic proximity Read ↗

DNA Polymerase ζ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic AgentsSemantic proximity Read ↗

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cellsSemantic proximity Read ↗

Targeting DNA polymerase ß for therapeutic intervention.Semantic proximity Read ↗

Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.Semantic proximity Read ↗

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate ExtenderSemantic proximity Read ↗

Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA RepairSemantic proximity Read ↗

Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.