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Article

Mutations within conserved motifs in the 3'-5' exonuclease domain of herpes simplex virus DNA polymerase.

The Journal of general virology - 1 Dec 1995

Hall J D, Orth K L, Sander K L, Swihart B M, Senese R A

Abstract excerpt

We investigated mutations within the presumed 3'-5' exonuclease domain of the DNA polymerase from herpes simplex virus type 1. The mutation sites correspond to residues in DNA polymerase I (Escherichia coli) which bind two metal ions that are required for exonuclease function. To evaluate the effect of the herpesvirus mutations on enzymatic activity, we overexpressed the wild-type DNA polymerase and one mutant...

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PMID: 8847505
DOI: 10.1099/0022-1317-76-12-2999

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