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Article

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2026

Longmire Pierce, Chen Han, McKinzey David R, Savanagouder Mamata, Kosarek Noelle N, Pesola Jean M, Bobak Carly A, Bosco Giovanni, Goodrum Felicia, Coen Donald M

Abstract excerpt

How host functions affect resistance to antiviral drugs is poorly understood. Ganciclovir, a chain-terminating nucleoside analog, is a first-line therapy against human cytomegalovirus, a widespread herpesvirus that causes life-threatening disease in immunocompromised individuals and newborns. Ganciclovir resistance, which is caused by mutations that affect the viral kinase, UL97, and/or the viral polymerase,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42607204
DOI: 10.1073/pnas.2618057123
PMCID: PMC13483331

Genes

XPA

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