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A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs' Susceptibility.

Viruses - 21 Nov 2024

Yamada Souichi, Harada Shizuko, Fujii Hikaru, Kinoshita Hitomi, Nguyen Phu Hoang Anh, Shibamura Miho, Yoshikawa Tomoki, Kawahara Madoka, Ebihara Hideki, Saijo Masayuki, Fukushi Shuetsu

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) acyclovir (ACV) resistance is acquired by mutations in the viral thymidine kinase (TK) or DNA polymerase (DNApol) genes. We previously obtained an ACV-resistant clone (HSV-1_VZV_TK_clone α) by sequential passages of HSV-1_VZV-TK, a recombinant virus which lacked its endogenous TK activity and instead expressed the varicella-zoster virus (VZV) TK ectopically. HSV-1_VZV_TK_clone...

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PMID: 39772124
DOI: 10.3390/v16121813

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