Article
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Journal of virology - 1 Oct 1997
Hwang Y T, Liu B Y, Coen D M, Hwang C B
Abstract excerpt
The herpes simplex virus DNA polymerase catalytic subunit, which has intrinsic polymerase and 3'-5' exonuclease activities, contains sequence motifs that are homologous to those important for 3'-5' exonuclease activity in other polymerases. The role of one such motif, Exo III, was examined in thi...
Topics
- Amino Acid Sequence
- Animals
- Cattle
- Cell Line
- Chlorocebus aethiops
- DNA-Directed DNA Polymerase
- Exodeoxyribonucleases
- Genes, Viral
- Genetic Complementation Test
- Humans
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Recombinant Proteins
- Sequence Alignment
- Sequence Homology, Amino Acid
- Simplexvirus