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Article

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.

Journal of virology - 1 Dec 2017

Grady Lorry M, Szczepaniak Renata, Murelli Ryan P, Masaoka Takeshi, Le Grice Stuart F J, Wright Dennis L, Weller Sandra K

Abstract excerpt

The herpes simplex virus (HSV) type I alkaline nuclease, UL12, has 5'-to-3' exonuclease activity and shares homology with nucleases from other members of the Herpesviridae family. We previously reported that a UL12-null virus exhibits a severe defect in viral growth. To determine whether the growth defect was a result of loss of nuclease activity or another function of UL12, we introduced an...

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Identifiers

PMID: 28956767
DOI: 10.1128/JVI.01380-17
PMCID: PMC5686714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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