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Article

Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.

Journal of virology - 1 Mar 2003

Hwang Ying T, Hwang Charles B C

Abstract excerpt

The effect of exonuclease activity of the herpes simplex virus DNA polymerase (Pol) on DNA replication fidelity was examined by using the supF mutagenesis assay. The recombinants with exonuclease-deficient Pol, containing an integrated supF gene in the thymidine kinase locus (tk), exhibited supF mutation frequencies ranging from 0.14 to 5.6%, consistent with the tk mutation frequencies reported previously (Y. T....

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Identifiers

PMID: 12584319
DOI: 10.1128/jvi.77.5.2946-2955.2003
PMCID: PMC149784

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Source receipt: pubmed, retrieved 7 Sept 2026.

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